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週次 |
日期 |
單元主題 |
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第1週 |
2/23 |
Multimodal structural analysis towards a platform technology to develop lifestyle medicines
Dr. R. Holland Cheng, Professor, Dept. Molecular & Cellular Biology, University of California, Davis |
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第2週 |
3/02 |
張法理 Expression of Arabidopsis hexokinase in citrus guard cells controls stomatal aperture and reduces transpiration. Frontiers in Plant Science 6: 1114, 2015
林煥宇 E. coli metabolic protein aldehydealcohol dehydrogenase-E binds to the ribosome: a unique moonlighting action revealed. Sci Rep 6: 19936, 2016 |
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第3週 |
3/09 |
陳容碩 A moonlighting metabolic protein influences repair at DNA double-stranded breaks. Nucleic Acids Res. 43(3): 1646–1658, 2015
林煜晟 Moonlighting transcriptional activation function of a fungal sulfur metabolism enzyme. Sci Rep. 6:25165, 2016 |
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第4週 |
3/16 |
林彥霐 Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution. Cell Metab. 23:554–562, 2016
高子萱 Running-induced systemic cathepsin B secretion is associated with memory function. Cell Metab. 24:332–340, 2016 |
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第5週 |
3/23 |
黃柏翰 Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway. Aging Cell 15:1082-1091, 2016
呂芝瑩 Pyruvate Kinase M2 Regulates Hif-1a Activity and IL- 1b Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages. Cell Metab. 21:65-80, 2015 |
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第6週 |
3/30 |
李孟億 Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib. Autophagy 10:1120–1136; 2014
譚安絜 Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia. Autophagy, 12:6, 1029-1046, 2016 |
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第7週 |
4/06 |
張智婷 Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo. Redox Biology 11:219-230, 2017
袁芸婷 Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation. Molecular Cell 57, 456–466, 2015 |
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第8週 |
4/13 |
陳一鳴 Development and Applications of CRISPR-Cas9 for Genome Engineering. Cell 157:1262-1278, 2014
蘇俊融 A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape. Sci Rep. 7:41968, 2017
鍾建弘 New CRISPR–Cas systems from uncultivated microbes. Nature 2017, 542 (7640), 237-241 |
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第9週 |
4/20 |
游閔亦 Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response. Mol. Cell 65: 1-8, 2017
劉沅瓚 Optimization of CRISPR/Cas9 genome editing to modify abiotic stress responses in plants. Scientific Reports, 6, 26685. 2016 |
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第10週 |
4/27 |
翁顥誠 Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell, 145(5): 732-744, 2011
林珆安 Moonlighting glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH): an evolutionarily conserved plasminogen receptor on mammalian cells |
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第11週 |
5/04 |
吳佳霖 Do nucleic acids moonlight as molecular chaperones? Nucleic Acids Res 44:4835–4845, 2016
陸沅君 A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase-extensive moonlighting in mitochondrial tRNA biogenesis. Nucleic Acids Res 40:11583-11593, 2012. |
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第12週 |
5/11 |
張雅晴 Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP. Sci Rep 7:40789, 2017
柯傅瑄 Exercise Induces Hippocampal BDNF through a PGC-1a/FNDC5 Pathway. Cell Metabolism 18: 649–659, 2013 |
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第13週 |
5/18 |
杜婉菁 Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways. Sci Rep. 6:18732, 2016
劉洋志 Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature 527:240–244,2015 |
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第14週 |
5/25 |
張孟亭 HS1BP3 Negatively Regulates Autophagy by Modulation of Phosphatidic Acid Levels. Nat Commun 7:13889, 2016
張婷宇 The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death. J Neurochem 134(6):1091-1103, 2015
江奕緯 The inhibition of lung cancer cell migration by AhR-regulated autophagy.
Sci Rep 7:41927, 2017 |
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第15週 |
6/01 |
邱俊瑜 Genetic inhibition of autophagy promotes p53 loss-ofheterozygosity and tumorigenesis. Oncotarget 7: 67919-67933, 2016
馬蓁華 Aspartyl Protease-Mediated Cleavage of BAG6 Is Necessary for Autophagy and Fungal Resistance in Plants. The Plant Cell, 28: 233-247, 2016 |
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第16週 |
6/08 |
李意涵 Programmable RNA Tracking in Live Cells with CRISPR/Cas9. Cell 165: 488-496, 2016
邱宇恩 In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Science 351(6271):403-7, 2016 |
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第17週 |
6/15 |
何嘉晉 CRISPR/Cas9-Induced Double-Strand Break Repair in Arabidopsis Nonhomologous End-Joining Mutants. G3 (Bethesda) 7(1): 193-202, 2017
黃云宣 Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Research 23:1163-1171, 2014 |